NanoKnife
NanoKnife
Irreversible Electroporation
Irreversible electroporation with NanoKnife™ technology represents an evolution in tumour ablation: a non-thermal platform designed for complex anatomical sites, which preserves the integrity of critical structures (organs, blood vessels, bile ducts, neuromuscular bundles).
Irreversible Electroporation: NanoKnife
Non-thermal oncologic ablation.
NanoKnife™ technology does not use heat and acts at cellular level, inducing apoptosis while preserving the integrity of vascular and biliary structures.
NanoKnife technology ensures Precision in treatment, Preservation of critical structures, Control of the treatment.
The unique features of NanoKnife™ technology:
- Non-thermal ablation
- Preservation of neurovascular bundles
- Reduced functional impact
- Intermediate option between active surveillance and radical surgery
- Possibility of re-treatment
NanoKnife™ technology in prostate cancer
NanoKnife focal therapy redefines the treatment of localized prostate cancer by preserving the anatomical structures responsible for urinary and erectile function.
NanoKnife™ technology introduces a therapeutic model oriented to quality of life, while maintaining oncologic control and treatment selectivity.
NanoKnife™ technology in the hepatobiliary district
Treating what was previously considered untreatable.
In the liver and peri-biliary district, proximity to vessels and ducts represents a challenge for thermal ablation techniques.
NanoKnife™ technology overcomes this limit. Thanks to its non-thermal nature:
- No heat-sink effect
- Preserves hepatic vessels and bile ducts
- Maintains stromal architecture
Indications: lesions close to vascular structures; hepatocellular carcinoma (HCC) and colorectal liver metastases (CRLM); cholangiocarcinoma.
NanoKnife™ technology in the pancreas
Pancreatic cancer is one of the most complex challenges in oncology, especially in locally advanced unresectable cases where involvement of major vessels limits therapeutic options.
Indications:
- Locally advanced pancreatic adenocarcinoma (LAPC)
- Unresectable tumors due to vascular involvement
- Patients after systemic therapy with stable disease
- Combined approach with surgery or other loco-regional strategies
NanoKnife™ technology integrates into multidisciplinary pathways as a complementary technology to surgery and systemic therapy.